Mesoporation is a specialized transdermal delivery technique that creates temporary microscopic channels in the skin’s surface through mechanical microperforations, enabling enhanced penetration of active substances into the dermis and epidermis. The process operates at the mesoscopic scale, between 1 and 100 micrometers, targeting the skin’s natural barrier function.
The technique employs precision-engineered microstructures that create uniform, controlled disruptions in the stratum corneum without causing significant tissue damage. These temporary channels facilitate the delivery of high-molecular-weight compounds, including peptides, proteins, and other bioactive molecules that normally cannot penetrate intact skin.
Mesoporation differs from traditional microneedling by utilizing non-invasive mechanical forces to create transient pathways. The process stimulates natural skin repair mechanisms, inducing localized metabolic activity and cellular regeneration. This method achieves superior bioavailability of topically applied substances while maintaining skin barrier integrity, making it valuable for both cosmetic and therapeutic applications.
