Microfractional is a therapeutic skin rejuvenation technology that creates microscopic thermal zones of controlled injury within the dermis, stimulating natural healing processes through fractional photothermolysis. This precision-based treatment utilizes laser or radiofrequency energy to generate thousands of microscopic treatment zones per square centimeter.

The technology penetrates the skin at depths ranging from 200 to 700 micrometers, creating columns of thermal damage while leaving surrounding tissue intact. These microinjuries trigger fibroblast activation, neocollagenesis, and elastin production through selective photothermolysis and heat-shock protein activation.

The biological response includes rapid re-epithelialization within 24 hours, followed by a cascade of healing mechanisms lasting 3-6 months. Clinical applications encompass treatment of photoaging, acne scarring, melasma, and striae distensae. The fractional approach maintains a favorable safety profile by preserving tissue bridges between treatment zones, enabling rapid healing and minimal downtime compared to traditional ablative procedures.