Microwounding is a controlled tissue injury technique that creates microscopic dermal wounds to stimulate the body’s natural healing response and cellular regeneration mechanisms. The process induces precise micro-trauma at specific depths ranging from 0.1 to 2.0 millimeters within the skin’s structural layers.
The induced microtrauma activates platelets and inflammatory mediators, triggering a cascade of growth factors including PDGF, TGF-β, and VEGF. These biochemical signals initiate fibroblast migration, neocollagenesis, and neoangiogenesis in the treated area. The resulting wound healing response occurs in three distinct phases: inflammation (0-3 days), proliferation (3-14 days), and remodeling (14-365 days).
This therapeutic approach employs various mechanical, thermal, or chemical methods to create standardized micro-injuries. The controlled damage pattern stimulates the production of type I and III collagen, elastin, and glycosaminoglycans, leading to tissue reorganization and structural improvement. Clinical applications include scar remodeling, skin rejuvenation, and enhancement of transdermal drug delivery systems.
