Nanopuncture is a minimally invasive therapeutic technique utilizing nano-scale needles to deliver bioactive compounds directly into cellular structures through precisely controlled microperforation of the stratum corneum. The procedure employs arrays of nanoscale projections, typically measuring 100-1000 nanometers in diameter, manufactured from biocompatible materials.
These nano-needles penetrate the epidermis at depths between 50-200 micrometers, creating temporary microchannels for enhanced transdermal delivery of therapeutic agents. The technology incorporates smart materials that respond to specific biological triggers, enabling targeted release of active ingredients at predetermined tissue depths.
The nanoscale architecture facilitates cellular interaction without triggering inflammatory responses or nerve stimulation, distinguishing it from traditional microneedling techniques. The process induces localized microtrauma at the molecular level, stimulating natural healing mechanisms while maintaining structural integrity of surrounding tissues. Applications include precision drug delivery, cosmetic treatments, and regenerative medicine protocols, with demonstrated efficacy in delivering growth factors, peptides, and other biomolecules across the skin barrier.
